School Program
The 2nd course of the International School on Mass Spectrometry consists of:
a) Tutorial lectures (60-120 mins) aimed at presenting theory, instrumentation and applications of ion mobility mass spectrometry given by an international team of lecturers;
b) Poster sessions. Participants are encouraged to present a poster on their own research activity. Posters will be exhibited during the full period of the school to give the opportunity to those attending the school to go through;
c) Selected flash orals (10 mins each). Selected posters will be presented as flash oral communications to give students the opportunity to present their work;
d) Exercises with the active participation of students in solving them on matters presented in the lectures;
e) Problem solving in which students present to the others and tutors problems encountered in their scientific activity receiving suggestions on how to try to solve them.
f) Social program consisting of:
Welcome party Monday, Sept. 9th, 8:00 p.m.
Excursion to Marsala and Selinunte
Guided Tour. Thursday, Sept. 12th, 3:00-8:00 p.m.
Gala Dinner Thursday, Sept. 12th, 8:30 p.m.
Students of the IntSMS 2024 leave their mark! Friday, Sept. 13th, 9:15 p.m.
| Monday September 9th |
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| 12:00÷ 5:00 p.m. |
Shuttle transfer from the airports in Trapani and Palermo to Erice | ||
| 6:00 p.m. | Registration | ||
| 6:30 p.m. | Welcome address. Presentation of the school | ||
| 7:00 p.m. |
Opening lecture
Gianluca Giorgi (Univ. of Siena, Italy), David E. Clemmer (Indiana Univ., USA) Mass spectrometry: state of the art and beyond |
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| 8:00 p.m. | Welcome party | ||
| Tuesday September 10th |
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Introduction to ion mobility: fundamentals, experimental cross sections, molecular simulations, and cross section calculations for structural analysis
Perdita Barran (Univ. of Manchester, UK), Valérie Gabelica (Univ. of Geneva, Switzerland) |
8:30 a.m. | Ion mobility mass spectrometry: background, introduction, and fundamentals of the measurements (types of mobility analyzers, timescales, resolving power) | |
| 10:15 a.m. | Coffee break & poster session | ||
| 11:00 a.m. | Obtaining CCS values from ion mobility measurements, the role of gas, temperature, instrument and molecular ion. Introduction to computational approaches to generate CCS values from input structures, and how we (carefully) compare values from experiment and theory | ||
| 12:45 p.m. | End of session | ||
| 1:00 p.m. | Lunch | ||
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Instrumentation: Drift tube-, T-wave-, trapping-, and Field Asymmetric Waveform IMS (FAIMS)
Jakub Ujma (Waters, Wilmslow, UK), Alexandre Shvartsburg (Wichita State Univ., USA) |
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| 3:00 p.m. | Drift-tube and traveling-wave based IMS-MS instrumentation and methods | ||
| 4:30 p.m. | Coffee break & poster session | ||
| 5:30 p.m. | Trapping IMS & FAIMS | ||
| 7:00 p.m. | End of session | ||
| 8:00 p.m. | Dinner | ||
| Wednesday September 11th |
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Mixtures and Discovery: Proteomics, Glycomics, Metabolomics, Lipidomics, & Exposomics
Erin Baker (Univ. N. Carolina, USA), Alina D. Zamfir (Univ. of Arad, Romania) |
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| 8:30 a.m. | Multidimensional IMS-MS Separations for Complex Mixture Analysis: Advantages and Challenges | ||
| 9:00 a.m. | Proteomic and Glycomic Analyses | ||
| 10:15 a.m. | Coffee break & poster session | ||
| 11:00 a.m. | Metabolomic, Lipidomic & Exposomic Analyses | ||
| 12:00 a.m. | Database Building, Searching, and Exercises | ||
| 12:45 p.m. | End of session | ||
| 1:00 p.m. | Lunch | ||
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Computational and experimental strategies for large datasets: Fundamental considerations and advanced techniques
John McLean (Vanderbilt Univ., USA), Stephen Valentine (Univ. of West Virginia, USA) |
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| 3:00 p.m. | Fundamental considerations for CCS prediction, contemporary computational tools, and addition of orthogonal measurements | ||
| 4:45 p.m. | Coffee break & poster session | ||
| 5:30 p.m. | Applications incorporating additional data dimensions: reaction chemistries, spatial measurements, large-scale data interrogation | ||
| 7:15 p.m. | End of session | ||
| 7:30 p.m. | Dinner | ||
| 9:15 p.m. | Problem solving/Troubleshooting. Questions … and drinks | ||
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Thursday September 12th |
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Higher-order structural analysis: IMS-SID-MS, IMS-IMS-MS, IMS-CIU-MS, and FT-IMS-MS
Brandon Ruotolo (Univ. of Michigan, USA) |
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| 8:30 a.m. | Fundamental principles and equipment: ion activation combined with ion mobility methods | ||
| 10:15 a.m. | Coffee break & poster session | ||
| 11:00 a.m. | Case studies: ion activation techniques combined with ion mobility in action | ||
| 12:45 p.m. | End of session | ||
| 1:00 p.m. | Lunch | ||
| Excursion and gala dinner. Have fun!! | |||
| 2:30 p.m. | Excursion to Marsala and Selinunte: guided tour | ||
| 8:30 p.m. | Gala dinner | ||
| 11:00 p.m. | Go back to Erice | ||
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Friday September 13th |
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Structure and stability in solution: using gas-phase ions to characterize solution structures
Michal Sharon (Weitzmann Inst., Israel), David E. Clemmer (Indiana Univ., USA) |
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| 8:30 a.m. | Using gas-phase ions to follow complex structural transitions in solution | ||
| 10:15 a.m. | Coffee break & poster session | ||
| 11:00 a.m. | Characterizing the physical properties of molecules in solution by IMS-MS: understanding reactivity and stability | ||
| 12:45 p.m. | End of session | ||
| 1:00 p.m. | Lunch | ||
| Short orals, exercises | |||
| 3:00 p.m. | Short orals by students
OR1 P1 Improving selectivity to quantify biotherapeutics in complex matrices. Differential mobility separation to avoid immunocapture interferences Francesco Molinaro, Ilse De Salve Merck KgaA, RBM S.p.a. Colleretto Giacosa (TO), Italy OR2 P3 Effects of polyethylene nanoparticles (PE-NPs) on lettuce leaves: insights from Ion Mobility Mass Spectrometry-based lipidomics approach Pier Paolo Becchi, Leilei Zhang, Luigi Lucini Università Cattolica del Sacro Cuore, Piacenza, Italy OR3 P8 Capturing the oligomerization dynamics of ALS-related Cu/Zn superoxide dismutase with temperature-controlled nESI and cyclic IMS Despoina Svingou, Julian Alexander Harrison, Renato Zenobi ETH Zurich, Zurich, Switzerland OR4 P12 Using mass spectrometry methods to aid the development of novel photo-enzymes: ion mobility and collision-induced unfolding for the characterisation of de novo designed α-helical barrels Ana Bath Alén, Liuwei Meng, Harry Spacey, Junfeng Ma, Katarzyna Ozga, Jason Kalapothakis, Dek Wolfson, Nigel Scrutton, Perdita Barran University of Manchester, Manchester, United Kingdom OR5 P14 Utilizing trapped ion mobility separation for enhanced lipid coverage in RP-UHPLC/MS analysis of biological samples Veronika Šubrtová, Robert Jirásko, Michal Holčapek University of Pardubice, Pardubice, Czech Republic OR6 P20 Frauds in truffle species: detection of marker compounds using SPME-GC-MS and LC-ESI-IM-QTOF-MS Pedro Gabriel Martínez Aznar, Pedro Marco, Markus Fischer, Marina Creydt, Eva Tejedor-Calvo Agrifood Research and Technology Centre of Aragón (CITA), Zaragoza, Spain OR7 P21 Digestibility and immunogenic peptide profile of pastas produced from evolutionary populations of wheat vs. traditional wheat varieties Alejandra Muñoz-González, Laura Gazza, Silvia Folloni, Salvatore Ceccarelli, Gianni Galaverna, Barbara Prandi, Tullia Tedeschi University of Parma, Parma, Italy OR8 P23 An overview of internal energy in mass spectrometry sources, a key factor impacting ion mobility measurement results Emilie Bertrand, Valérie Gabelica University of Geneva, Switzerland OR9 P28 Characterization of the oligomeric structure of bird hemoglobin by mass spectrometry under native conditions Turkan Nabiyeva, Léa Letissier, Maïly Kervella, Stéphane Hourdez, Christine Schaeffer, François Criscuolo, Fabrice Bertile, Sarah Cianferani, Oscar Hernandez-Alba University of Strasbourg, Strasbourg, France OR10 P31 Novel strategies for the characterization of the early-stages of aggregate formation of α-synuclein using ion mobility mass spectrometry Andrea Istrati, Raya Sadighi, Melissa Bärenfänger, Anouk M. Rijs Vrije Universiteit Amsterdam, The Netherlands |
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| 4:40 p.m. | Coffee break | ||
| 5:10 p.m. | Leveraging ion mobility in complex sample analysis: an in-depth exploration of techniques and applications
Hannah Florance (Agilent, UK) |
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| 5:30 p.m. | Exercises | ||
| 7:00 p.m. |
Award for the best short oral! Award for the best poster! Award for the best IMMS solver! |
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| 7:10 p.m. | End of session | ||
| 8:00 p.m. | Dinner | ||
| 9:15 p.m. | Students of the IntSMS 2024 leave their mark! | ||
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Saturday September 14th |
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Food and drug applications
Ane Arrizabalaga-Larrañaga (Wageningen, The Netherlands), Christopher D. Chouinard (Clemson University, USA) |
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| 8:30 a.m. | Ion mobility mass spectrometry for food analysis | ||
| 10:00 a.m. | Coffee break | ||
| 10:30 a.m. | Ion mobility mass spectrometry for drug analysis | ||
| 12:00 p.m. | Meeting students-tutors | ||
| 12:30 p.m. | Concluding remarks and Arrivederci! | ||
| 1:00 p.m. | Shuttle bus to the airports in Trapani and Palermo | ||
Download the IntSMS 2024 program:
intsms2024-program.pdf 
